ABSTRACT
Objective@#To evaluate the impact of long-term treatment with Entecavir(ETV)on renal function in elderly patients with chronic hepatitis B(CHB).@*Methods@#Elderly patients with CHB receiving ETV(0.5 mg/d)antiviral therapy who were followed up for 234 weeks in Beijing Friendship Hospital were retrospective analyzed.The estimated glomerular filtration rate(eGFR)(CKD-EPI creatinine formula)was used to evaluate renal function changes at baseline and 52, 104, 156, 208 and 234 weeks after treatment.@*Results@#A total of 40 included patients with CHB aged 60-81 years were enrolled, with baseline eGFR value(n=40) of (64.25±11.32)ml·min-1·1.73 m-2.The eGFR values at all time points after treatment were as following: (63.85±11.53)ml·min-1·1.73 m-2, (63.71±11.58)ml·min-1·1.73 m-2, (59.95±9.59)ml·min-1·1.73 m-2, (62.28±15.32)ml·min-1·1.73 m-2, (65.78±15.99)ml·min-1·1.73 m-2 at 52 weeks(40 cases), 104 weeks(40 cases), 156 weeks(38 cases), 208 weeks(36 cases)and 234 weeks(28 cases)after ETV treatment respectively.And the difference of eGFR values among all time points was not statistically significant(F=0.291, P=0.072). The results of the pairwise comparison showed that as compared with the baseline eGFR value, the eGFR values had no statistically significant difference at all time points after treatment(P>0.05). The baseline creatinine value in all 40 patients was(57.23±9.67)μmol/L.Creatinine values at 52 weeks(15 cases), 104 weeks(5 cases), 156 weeks(6 cases), 208 weeks(8 cases)and 234 weeks(6 cases)after ETV treatment, were(63.78±8.63)μmol/L, (67.86±11.21)μmol/L, (71.46±13.75)μmol/L, (68.22±8.99)μmol/L and(79.53±9.58)μmol/L respectively, with no significant difference(F=0.266, P=0.067). The results of the pairwise comparison showed that as compared with the baseline creatinine value, the creatinine values had no significant difference at all time points after ETV treatment(P>0.05).@*Conclusions@#ETV treatment has no effect on renal function in elderly patients with chronic hepatitis B.
ABSTRACT
Objective To evaluate the impact of long-term treatment with Entecavir(ETV)on renal function in elderly patients with chronic hepatitis B(CHB).Methods Elderly patients with CHB receiving ETV(0.5 mg/d)antiviral therapy who were followed up for 234 weeks in Beijing Friendship Hospital were retrospective analyzed.The estimated glomerular filtration rate (eGFR) (CKD-EPI creatinine formula)was used to evaluate renal function changes at baseline and 52,104,156,208 and 234 weeks after treatment.Results A total of 40 included patients with CHB aged 60-81 years were enrolled,with baseline eGFR value(n=40) of (64.25±11.32)ml · min-1 · 1.73 m-2.The eGFR values at all time points after treatment were as following..(63.85 ±11.53) ml · min-1 · 1.73 m-2,(63.71± 11.58)ml· min-1 · 1.73 m-2,(59.95±9.59)ml· min-1 · 1.73 m-2,(62.28± 15.32)ml· min-1 · 1.73 m-2,(65.78± 15.99)ml · min-1 · 1.73 m-2 at 52 weeks(40 cases),104 weeks(40 cases),156 weeks(38 cases),208 weeks(36 cases)and 234 weeks(28 cases)after ETV treatment respectively.And the difference of eGFR values among all time points was not statistically significant(F =0.291,P =0.072).The results of the pairwise comparison showed that as compared with the baseline eGFR value,the eGFR values had no statistically significant difference at all time points after treatment(P ＞ 0.05).The baseline creatinine value in all 40 patients was (57.23 ± 9.67) μmol/L.Creatinine values at 52 weeks(15 cases),104 weeks(5 cases),156 weeks(6 cases),208 weeks (8 cases)and 234 weeks(6 cases) after ETV treatment,were(63.78 ± 8.63)μmol/L,(67.86 ± 11.21) μmol/L,(71.46 ± 13.75) μmol/L,(68.22 ± 8.99) μmol/L and (79.53 ± 9.58)μmol/L respectively,with no significant difference(F =0.266,P =0.067).The results of the pairwise comparison showed that as compared with the baseline creatinine value,the creatinine values had no significant difference at all time points after ETV treatment(P＞0.05).Conclusions ETV treatment has no effect on renal function in elderly patients with chronic hepatitis B.